The determination of the preferential flow direction in a reservoir becomes a very important subject for the development of an oilfield, especially for the selection of the optimum exploitation strategy taking into account that porous media is a very complex environment in which representing the flow behavior of fluids becomes a tough task, mainly in carbonates where the distribution of fractures, lithology changes and diagenesis play a major role in this topic. Naturally Fractured Reservoirs (NFR) represent a great technical challenge for the petroleum industry because they behave as a heterogeneous medium with a strong influence of diagenesis, a term that encompasses fractures, dissolution, compaction, dolomitization, cementation and recrystallization to conform a reservoir with totally different distribution of properties. The dynamic data must be evaluated in order to match with the static model achieving a good reservoir characterization. In this paper we present a way to determine the preferential flow direction by the monitoring of the field through permanent real-time downhole gauges that allowed the identification of the interference between wells in a deep naturally fractured reservoir that originally did not show any degree of communication. Suddenly, after some producing time, the field demonstrated a great level of interference among wells and as a consequence, the determination of the preferential flow direction was possible through Pressure Transient Analysis (PTA) and Rate Transient Analysis (RTA).