Since late 2017, the Haynesville Shale has seen an uptick in activity as more operators have started to drill more new shale wells than at any other time since the industry was slowed due to declining oil price at the end of 2014. Some of the new activity has been focused on pushing the economic boundaries of the Haynesville shale out whereas others have focused on drilling infill wells or wells that are drilled between pre-existing wells (known as "parent wells"). Parent wells may cause pressure depletion in the reservoir, potentially hindering the performance of new infill wells. The distance from the parent well to an infill well along with the degree of reservoir depletion caused by the parent well impact, to varying degrees, the production results of the infill wells. It is important to design a completion program in the infill well that minimizes the potential negative impact of depletion. This paper presents detailed studies assessing the impact of the change in offset well spacing and reservoir depletion related to parent wells on infill well performance through modeling in the Haynesville shale. An actual reservoir dataset was utilized in the Haynesville shale to build the parent well hydraulic fracture and reservoir simulation models to account for fracture calibration and production history matching. The models' results were then used to evaluate the impact of production depletion on the stress reorientation and changes in stress magnitude through a coupled boundary element and finite element model residing in a geomechanics simulator. Three different production depletion times were modeled through the simulation, 0.5, 1, and 3 years, to understand the timing impact on the infill well production. After the stress in the model was updated for each case, a child well pad was added to the model adjacent to the parent well. The well spacing, stimulation job treatment, and fracture stimulation pump rates were all varied for child well simulation and evaluated to understand their impacts on the created complex fracture propagation and total system hydrocarbon recovery. In this study, more than 200 different scenarios were simulated by using cloud computation, and each parameter was compared for varying spacing scenarios for the three depletion time horizons. This study can help the understanding of well spacing, completion job design, and reservoir depletion impact on the new infill well performance and help the optimization of the infill well completion strategy to achieve optimum production performance for new infill wells and minimize communication or fracture hits to the existing parent wells in the Haynesville.