The complete paper describes a physics-based model of interference and a sensitivity study to propose guidelines for well spacing and a drilling timeline for multiple horizontal wells in the Vaca Muerta shale. The state-owned firm is looking within its home country, around Southeast Asia, and to the Americas—including shale—in an effort to maintain its forecast average yearly production of 1.7 million BOE/D over the next 5 years. Vaca Muerta production is on the upswing. Will increasing activity propel the Argentine play to the ranks of US shale? Data suggest it is both already there and has a ways to go.