In this paper, sand screen integrity in two depleting reservoirs is evaluated using fluid-mechanical coupling analysis. Both analyses use a numerical model for rock-structure interaction. In the first, a horizontal completion in a soft sandstone reservoir is evaluated. This analysis used laboratory tests to measure the properties of ceramic proppant, the formation sandstone and sand screen. The numerical model included friction hardening and volumetric hardening of the formation, friction hardening of the gravel pack, and the crushing strength of the screen base pipe which were all measured in the laboratory. In the second, a vertical gravel pack in a stiff strong formation was analyzed to evaluate gravel screen contact loads under very high levels of depletion and drawdown. While this analysis did not include a laboratory program, using instead existing core data, it did model the effect of near wellbore damage on the contact load. The results show that loads on sand control completions can be estimated and the workflow demonstrated here is a way to select durable sand control completions.