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Oil, gas, water, steel, and rock are not always chemically inert under oil/gas production conditions. Their mutual interactions, induced in part by changes in pressure and temperature, can lead to the accumulation of solids, both organic and inorganic (scaling) within the production system, as well as deterioration of the metals that the fluids contact (corrosion). This chapter discusses these effects in terms of root causes, the operational difficulties resulting, and the principles/methods that have been used to cope. Case histories are not presented in any detail, but references are given to specific papers dealing with cause/effect/cure examples. It is assumed that the reader is not an expert in things chemical but does have a passing acquaintance with the jargon of chemistry and with some of the general principles underlying chemical processes. "Well production problems" are taken as starting when fluids enter the wellbore and end when fluids reach the storage/treatment facilities. Problems arising from adverse chemistry, occurring in the formation, are discussed elsewhere in the literature. The disposal of toxic coproduction [e.g., H2S, Hg, and naturally occurring radioactive materials (NORM)] is mentioned briefly in this chapter and is discussed in the chapter on facilities in the Facilities and Construction Engineering section of thisHandbook. This chapter also does not treat the flow engineering problems, multiple-phase production problems, and the in-situ measurement/control problems attendant to producing hydrocarbons.